Content analysis of conversations on Reddit: reactions to FDA's ENDS prioritized enforcement policy.

Introduction: On January 2, 2020, the FDA announced a policy focused in part on prioritizing enforcement of flavored (other than tobacco- or menthol-flavored) cartridge-based electronic nicotine delivery systems (ENDS) without premarket authorization.

Methods: We used a query to identify Reddit conversations relevant to the policy from January 2 to May 6, 2020. Our sample included 576 posts (46 posts and 530 accompanying comments).

Outcomes of a Population-Based Congenital Cytomegalovirus Screening Program.

Importance: Detection of congenital cytomegalovirus (cCMV) infection has previously relied on targeted screening programs or clinical recognition; however, these approaches miss most cCMV-infected newborns and fail to identify those infants who are asymptomatic at birth but at risk for late-onset sensorineural hearing loss.

Objective: To determine the feasibility of using routinely collected newborn dried blood spots (DBS) in a population-based cCMV screen to identify infants at risk for hearing loss and describe outcomes of infants screened.

Design, Setting, And Participants: This diagnostic study of a population-based screening program in Ontario, Canada, took place from July 29, 2019, to July 31, 2023.

Impact of the COVID-19 pandemic on primary care for hypertension in the UK: a population-based cohort study.

Objectives: To describe the impact of the COVID-19 pandemic on hypertension diagnosis and management in UK primary care.

Design: Population-based cohort study.

Setting: Over 2000 general practices across the UK contributing to the Clinical Practice Research Datalink.

Bayesian Analytical Methods in Cardiovascular Clinical Trials: Why, When, and How.

The Bayesian analytical framework is clinically intuitive, characterised by the incorporation of previous evidence into the analysis and allowing an estimation of treatment effects and their associated uncertainties. The application of Bayesian statistical inference is not new to the cardiovascular field, as illustrated by various recent randomised trials that have applied a primary Bayesian analysis. Given the guideline-shaping character of trials, a thorough understanding of the concepts and technical details of Bayesian statistical methodology is of utmost importance to the modern practicing cardiovascular physician.

Action needed to address molecular HIV surveillance ethical concerns.

There have been growing ethical concerns about the widespread use of HIV-related molecular epidemiological public health surveillance and research-or what has come to be known as molecular HIV surveillance. The varied concerns of the practice originate due to lack of informed consent, lack of demonstrated benefit for communities, potential for eroded patient care relationships leading to poor health outcomes, and potential implications for information sharing and findings which could increase stigmatization and other negative impacts in contexts where HIV, drug use, sex work, migration, and poverty are criminalized. As people living with HIV, lawyers, clinicians, and social scientists, we are part of the growing movement calling for critical and ethical attention to the practice of molecular HIV surveillance and the public health logic which underwrites the practice.