Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma.

Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been implicated in bone destruction, tumor survival and metastases during OS. We examined the role of Dkk-1 in OS disease progression and explored strategies for targeting its activity.

Using Video Cameras to Assess Physical Activity and Other Well-Being Behaviors in Urban Environments: Feasibility, Reliability, and Participant Reactivity Studies.

Background: Unobtrusive observation is a promising method for assessing physical activity and other well-being behaviors (eg, social interactions) in urban environments, without participant burden and biases associated with self-report. However, current methods require multiple in-person observers. Using video cameras instead could allow for more accurate observations at lower cost and with greater flexibility in scheduling.

Service Users' Experiences of a Nationwide Digital Type 2 Diabetes Self-Management Intervention (Healthy Living): Qualitative Interview Study.

Background: Diabetes Self-Management Education and Support programs for people living with type 2 diabetes mellitus (T2DM) can increase glycemic control and reduce the risk of developing T2DM-related complications. However, the recorded uptake of these programs is low. Digital self-management interventions have the potential to overcome barriers associated with attendance at face-to-face sessions.

Comparing the acute responses between a manual and automated blood flow restriction system.

Unlabelled: The purpose of this study was to compare acute responses between manual and automated blood flow restriction (BFR) systems.

Methods: A total of 33 individuals completed this study. On visit 1, arterial occlusion pressure (AOP, mm Hg), cardiovascular responses, and discomfort (RPE-D) were measured with each BFR system at rest.