Publications by authors named "J W Baer"
Background: Left atrial appendage (LAA) occlusion (LAAO) is performed to prevent LAA thrombus in patients with atrial fibrillation (AF). The risk of device-related thrombus (DRT) on the atrial side of the LAAO device is approximately 4%. Identifying patients at high risk of DRT would enable closer surveillance and more-aggressive anticoagulation to prevent post-LAAO DRT-related stroke.
View Article and Find Full Text PDFArticle Synopsis
- - Abscission is the intentional separation of plant organs, crucial for plant development and reacting to environmental changes; it is regulated in Arabidopsis by the receptor-like kinases HAESA (HAE) and HAESA LIKE-2 (HSL2) that manage the breakdown of connections between floral organs and fruit.
- - The study employs single-cell RNA sequencing to map the gene expression involved in abscission, identifying MKP1 as a negative regulator that sets a necessary threshold for HAE/HSL2 signaling before abscission occurs.
- - The research also reveals different gene expressions in subpopulations of abscission zone cells, with IDA family genes promoting HAE/HSL2 signaling in the distal cells
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is often resistant to therapy. An immune suppressive tumor microenvironment (TME) and oncogenic mutations in have both been implicated as drivers of resistance to therapy. Mitogen-activated protein kinase (MAPK) inhibition has not yet shown clinical efficacy, likely because of rapid acquisition of tumor-intrinsic resistance.
View Article and Find Full Text PDFArticle Synopsis
- Atrial fibrillation (AF) can weaken the left atrial appendage, increasing the risk of stroke, which can be measured through left atrial appendage emptying velocity (LAAev) via transesophageal echocardiogram (TEE).
- A study evaluated factors that lead to reduced LAAev (<30 cm/s) in patients with AF, using logistic regression to create a risk prediction model called the CHIRPM score based on various clinical and echocardiographic traits.
- The model was validated against a dataset, showing that both low and high CHIRPM scores significantly correlated with LAAev levels, offering a new way to assess stroke risk among individuals with AF.
Article Synopsis
- Multiple myeloma (MM) presents complex symptoms that require comprehensive management, and palliative care (PC) plays a crucial role in meeting patients' physical, psychosocial, and spiritual needs, though it is underutilized in MM treatment.
- A study of 22 MM patients in a palliative care unit found that the most common admission reasons were nutritional issues (82%), fatigue (77%), and pain (68%), with a significant portion dying during their stay.
- Results showed that while hospital stays varied, there was a notable reduction in symptom severity, highlighting the effectiveness of PC interventions in improving patients' quality of life through a multidimensional approach.