Publications by authors named "J W B Rae"
Article Synopsis
- Snakebite envenoming poses a significant public health risk in tropical areas, particularly in Malawi, where community understanding of local snakes and first-aid measures is lacking.
- A survey conducted in Neno District revealed that only 1.3% of participants could accurately identify snakes, less than 5% knew proper first-aid procedures, and 14.3% had adequate knowledge of prevention methods.
- The findings indicate that both community health workers and members have inadequate knowledge, showing no significant differences between the two groups.
Article Synopsis
- - The RSClinN+ tool was developed to better predict recurrence risk and the benefits of chemotherapy specifically for patients with HR+/HER2-negative, lymph node-positive breast cancer, by incorporating both the Oncotype DX score and other clinical factors like tumor size and age.
- - Analysis of data from over 5,000 patients revealed that RSClinN+ offered significantly improved prognostic accuracy compared to using the Oncotype DX score alone or clinicopathological models, especially for premenopausal and postmenopausal women.
- - Validation of RSClinN+ showed that it effectively estimates prognosis and potential chemotherapy benefits, making it a valuable personalized tool for clinicians in managing breast cancer treatment decisions.
Inhibition of estrogen receptor alpha (ERα) signaling is an established therapeutic approach for the treatment of ER-positive (ER+) breast cancers, but new therapeutic strategies are urgently needed to overcome clinical resistance. In the present study, we describe the discovery and extensive evaluation of ERD-12310A as an exceptionally potent and orally efficacious PROTAC degrader of ERα. ERD-12310A achieved a DC value of 47 pM and is 10 times more potent than ARV-471.
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- Current therapies for ERα-positive breast cancer often face challenges due to clinical resistance, creating a need for new treatment options.
- Researchers have discovered ERD-1233, an oral drug that effectively degrades the ERα protein through innovative PROTAC technology.
- In preclinical models, ERD-1233 shows significant tumor regression and growth inhibition, suggesting it could be a valuable new therapy for treating ER+ breast cancer.
Article Synopsis
- Specialized nurses play a vital role in implementing telehealth solutions aimed at enhancing quality and safety in home care, which is a key area of current healthcare research.
- A scoping review analyzed literature from 2013 to 2024, identifying 23 relevant studies that highlighted how specialized nurses utilize telehealth across various fields to ensure patient safety.
- Key findings included improvements in patient safety through better continuity of care, increased confidence, proactive monitoring, medication safety, patient engagement, and reduced healthcare costs.