Proton therapy reduces the effective dose to immune cells in breast cancer patients.

Background: The effective dose to circulating immune cells (EDIC) is associated with survival in lung and esophageal cancer patients. This study aimed to evaluate the benefit of intensity-modulated proton therapy (IMPT) for EDIC reduction as compared to volumetric modulated arc therapy (VMAT) in patients with locally advanced breast cancer (BC).

Materials And Methods: Ten BC patients treated with locoregional VMAT after breast-conserving surgery were included.

Determinants of radiation dose to immune cells during breast radiotherapy.

Background: The immune system has been identified as an organ at risk in esophageal and lung cancers. However, the dosimetric impact of radiotherapy on immune system exposure in patients treated for breast cancer has never been studied.

Methods: A monocentric retrospective dosimetric study included 163 patients treated at the Institut Curie (Paris, France) between 2010 and 2016 with locoregional helical tomotherapy after conservative surgery or total mastectomy.

Scripting a planning avoidance structure to perform simultaneous integrated boost breast on Halcyon linear accelerators.

When planning a simultaneous integrated boost in breast treatment with sliding window intensity-modulated radiotherapy, the use of an oblique anterior field can be advantageous. To limit the irradiation to the tumor bed on the oblique anterior field, we use the "fixed jaw" option during optimization in Eclipse (v15.6, Varian Medical System).

Dosimetric feasibility study ("proof of concept") of refractory ventricular tachycardia radioablation using proton minibeams.

Purpose: Preclinical data demonstrated that the use of proton minibeam radiotherapy reduces the risk of toxicity in healthy tissue. Ventricular tachycardia radioablation is an area under clinical investigation in proton beam therapy. We sought to simulate a ventricular tachycardia radioablation with proton minibeams and to demonstrate that it was possible to obtain a homogeneous coverage of an arrhythmogenic cardiac zone with this technique.

Large scale experience of two ultrahypofractionated 5 fractions regimes after breast conserving surgery from a single centre.

Purpose: Ultra-hypofractionation breast radiotherapy is a safe alternative to moderate hypofractionation. This study reports the results of two ultrahypofractionated regimens used in clinical practice in a high-volume radiotherapy center in terms of efficacy and of tolerance.

Methods: we included all patients treated in an adjuvant setting with five fractions after breast conserving surgery (BCS), for a histologically-confirmed invasive or breast carcinoma.