Gene Polymorphisms and DNA Methylation in Idiopathic Spontaneous Preterm Birth.

: Preterm birth (PTB) is a complex condition with various contributing factors, including genetic and epigenetic influences such as DNA methylation. Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in DNA methylation and the remethylation of homocysteine. This study aimed to investigate the association between maternal MTHFR C677T and A1298C polymorphisms, LINE-1 DNA methylation levels, and the risk of idiopathic spontaneous preterm birth (SPTB) in Caucasian women from Croatia and Slovenia.

The Impact of the COVID-19 Pandemic on Individuals with Down Syndrome: A Croatian Survey.

Background: Severe acute respiratory syndrome coronavirus-2 infection has spread uncontrollably worldwide. Among the most vulnerable groups in society are populations with multiple comorbidities, including individuals with Down syndrome (DS).

Aim: Our aim was to conduct an online survey to assess the impact of COVID-19 on DS individuals in Croatia.

Micronutrient status in children and adolescents with Down syndrome: systematic review and meta-analysis.

Background: Down syndrome (DS) is the most common genetic disorder. To date, the scientific literature regarding micronutrient status in children and adolescents with DS has not been systematically reviewed. Therefore, our aim was to provide a systematic review and meta-analysis on this topic.

rs2424913 as a Risk Factor for Congenital Heart Defects in Down Syndrome.

Impairments of the genes that encode enzymes that are involved in one-carbon metabolism because of the presence of gene polymorphisms can affect the methylation pattern. The altered methylation profiles of the genes involved in cardiogenesis may result in congenital heart defects (CHDs). The aim of this study was to investigate the association between the rs1801133, rs1801131, rs1801394, rs2228611, rs1550117, rs1569686, and rs2424913 gene polymorphisms and congenital heart defects in Down syndrome (DS) individuals.