Publications by authors named "J Votaw"
18F-flurpiridaz positron emission tomography segmental and territory myocardial blood flow metrics: incremental value beyond perfusion for coronary artery disease categorization.
Eur Heart J Cardiovasc Imaging
November 2022
Article Synopsis
- The study evaluated the effectiveness of segmental 18F-flurpiridaz myocardial blood flow (MBF) measurement by PET compared to traditional methods, focusing on its diagnostic performance in identifying coronary artery disease (CAD).
- In a trial with 245 patients, the segmental flow metrics showed better diagnostic performance than territory metrics, with significant improvements seen in the assessment of CAD with 50% stenosis using SMBF measurements.
- The findings suggest that using segmental MBF metrics is a feasible approach that enhances the detection of CAD, particularly when using SMBF alongside relative perfusion quantitation (PQ) for moderate cases, though it doesn't significantly improve performance for more severe cases (≥70
Background: We wished to document the prevalence and quantitative effects of compromised Rb PET data acquisitions on myocardial flow reserve (MFR).
Methods And Results: Data were analyzed retrospectively for 246 rest and regadenoson-stress studies of 123 patients evaluated for known or suspected CAD. An automated injector delivered pre-determined activities of Rb.
Article Synopsis
- The study developed an automated method for interpreting myocardial perfusion imaging (MPI) using F-flurpiridaz in patients, aiming for standardized and objective results.
- The analysis involved comparing the accuracy of automated quantitation against traditional visual interpretations using data from multiple clinical trials.
- Results indicated that the automated approach produced similar accuracy in detecting coronary artery disease (CAD) while showing improved consistency among reviewers compared to visual methods.
Background: Asynchrony has been reported to be a marker of ischemic-induced left ventricular dysfunction, the magnitude of which correlates with extent of epicardial coronary disease. We wished to determine whether normal-appearing arterial territories with mild degrees of asynchrony have lower Rb PET absolute myocardial blood flow (MBF) and/or lower myocardial flow reserve (MFR).
Methods And Results: Data were examined retrospectively for 105 patients evaluated for known/suspected CAD who underwent rest/regadenoson-stress Rb PET/CT and quantitative coronary angiography.