Genetic loci and metabolic states associated with murine epigenetic aging.

Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly conserved CpGs in 339 predominantly female mice belonging to the BXD family for which we have deep longevity and genomic data. We use a 'pan-mammalian' microarray that provides a common platform for assaying the methylome across mammalian clades.

Evaluation of Potential Transfer of the Pathogen between Farmed Salmonids and Wild Fish.

infections are among the main parasitic diseases affecting farmed salmonids. The distribution and potential transfer of spp. between farms and the natural environment has been scarcely investigated.

Body weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family.

DNA methylation (DNAm) is shaped by genetic and environmental factors and modulated by aging. Here, we examine interrelations between epigenetic aging, body weight (BW), and life span in 12 isogenic strains from the BXD family of mice that exhibit over twofold variation in longevity. Genome-wide DNAm was assayed in 70 liver specimens from predominantly female cases, 6-25 months old, that were maintained on normal chow or high-fat diet (HFD).

Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter.

Background: A long-term opioid use has been associated with hypermethylation of the opioid receptor mu 1 (OPRM1) promoter. Very little is currently known about the early epigenetic response to therapeutic opioids. Here, we examine whether we can detect DNA methylation changes associated with a few days' use of prescribed opioids.

Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults.

Background: Changes in DNA methylation over the course of life may provide an indicator of risk for cancer. We explored longitudinal changes in CpG methylation from blood leukocytes, and likelihood of future cancer diagnosis.

Methods: Peripheral blood samples were obtained at baseline and at follow-up visit from 20 participants in the Health, Aging and Body Composition prospective cohort study.