Publications by authors named "J Vieth"
Article Synopsis
- * Current research seeks to understand T1D and develop new treatments, including immune system modulation, β-cell regeneration, and advanced insulin delivery methods like closed-loop pumps and stem cell therapies.
- * Recent studies suggest that TNF-α inhibitors could help preserve β-cell function in people with advanced T1D, prompting experts to convene and plan pivotal clinical trials to further evaluate their effectiveness.
Article Synopsis
- The CAPRA trial evaluated the combination of Coxsackievirus A21 (V937) and pembrolizumab for treating advanced melanoma, focusing on safety as the primary outcome.
- In this study, 36 patients were treated, with a 47% objective response rate, including a 22% complete response rate, and 82% of responders maintaining their response for over 6 months.
- Notably, the trial found that tumor microenvironments in responders had lower CD3CD8 T cell density than nonresponders, indicating potential effectiveness even in less immunologically active tumors.
While the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood. We report a case of full resolution of severe COVID-19 due to convalescent plasma transfusion. Following transfusion, the patient showed fever remission, improved respiratory status, and rapidly decreased viral burden in respiratory fluids and SARS-CoV-2 RNAemia.
View Article and Find Full Text PDFBackground: Glutamate signaling activates MAPK and PI3K/AKT pathways in tumor cells. Treatment with riluzole, a glutamate release inhibitor, has been previously shown to be safe in melanoma patients and produced biologic effects, but did not lead to radiographic responses, possibly due to poor pharmacokinetic properties. Therefore, we conducted a phase Ib trial to determine the safety and tolerability of the combination of the riluzole prodrug troriluzole (BHV-4157, trigriluzole) and the PD-1 antibody nivolumab in patients with advanced solid tumors.
View Article and Find Full Text PDFBackground: While the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood.
Main Body: We report a case of full resolution of severe COVID-19 due to convalescent plasma transfusion in a patient with underlying multiple autoimmune syndrome. Following transfusion, the patient showed fever remission, improved respiratory status, and rapidly decreased viral burden in respiratory fluids and SARS-CoV-2 RNAemia.