Basic Science and Pathogenesis.

Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation method. Short-term tDCS protocols have shown positive effects on cognitive outcomes in Alzheimer's Disease (AD) populations. Less is known about the long-term benefits of tDCS on cognition in AD.

Clinical Manifestations.

Background: Mild parkinsonian signs (MPS) are prevalent in older adults and linked to an increased risk of dementia. However, their association with Motoric Cognitive Risk syndrome (MCR), a pre-dementia syndrome characterized by slow gait speed and cognitive complaints, is unclear. This study aims to examine the association of MPS with incident MCR.

Validation of a Malayalam Version of the Apathy Evaluation Scale.

Background: The apathy evaluation scale (AES) measures apathy, but its usefulness as a screening tool in diverse populations is limited without translation into more languages. To date, there is no reported translation of the AES into Malayalam, a language spoken by over 32 million people in the southern Indian state of Kerala. In the present study, we aimed to validate the Malayalam version of the AES.

Psychological predictors of incident subjective cognitive complaints in community dwelling older adults.

Background: Subjective cognitive complaint (SCC) is associated with future cognitive decline and may be a marker for clinical intervention in the progression to dementia. Among the viable predictors of SCC, psychological factors are clinically relevant, non-invasive early indicators of older adults at elevated risk.    This aim of this study is to determine whether psychological symptoms: dysphoria and apathy precede incident SCC in the dementia pathway.