Publications by authors named "J Venkatesan"
Article Synopsis
- Despite the lack of a cure for osteoarthritis, researchers aimed to address mitochondrial dysfunction by developing a new treatment that uses mitochondria to deliver gene therapy via recombinant adeno-associated viral (rAAV) vectors.
- The study demonstrated that this mitochondria/rAAV system could successfully increase the expression of insulin-like growth factor I (IGF-I) in human osteoarthritic chondrocytes, showing up to an 8.4-fold increase compared to controls.
- The strategy not only improved cell proliferation and survival but also boosted the production of the extracellular matrix and enhanced mitochondrial function, indicating its potential as a promising treatment for osteoarthritis.
Aptamers, single-stranded nucleic acids that bind to specific targets with high affinity and specificity, hold significant promise in various biomedical and biotechnological applications. The traditional method of aptamer selection, SELEX (Systematic Evolution of Ligands by EXponential Enrichment) takes a lot of work and time. Recent advancements in computational methods have revolutionized aptamer design, offering efficient and effective alternatives.
View Article and Find Full Text PDFBone tissue engineering is a growing field that provides solutions for the treatment of bone deformities, injuries, diseases, and anomalies by replacing autograft and allograft procedures. Various scaffolding materials have been used for the construction of bone tissue, including metals, ceramics, and polymers. This study investigates an innovative liquid exfoliation approach for the production of molybdenum disulfide (MoS) nanosheets using riboflavin (RF-MoS) as an exfoliation agent and subsequently analytically characterized for the development of bone scaffolding system.
View Article and Find Full Text PDFOsteoarthritis is a progressive, irreversible debilitating whole joint disease that affects millions of people worldwide. Despite the availability of various options (non-pharmacological and pharmacological treatments and therapy, orthobiologics, and surgical interventions), none of them can definitively cure osteoarthritis in patients. Strategies based on the controlled release of therapeutic compounds via biocompatible materials may provide powerful tools to enhance the spatiotemporal delivery, expression, and activities of the candidate agents as a means to durably manage the pathological progression of osteoarthritis in the affected joints upon convenient intra-articular (injectable) delivery while reducing their clearance, dissemination, or side effects.
View Article and Find Full Text PDFArticle Synopsis
- Hydroxyapatite (HA) is a widely used material in dental and orthopedic fields due to its compatibility with biological tissues and its ability to mimic bone properties, making it a popular choice for bone-graft substitutes.
- This study specifically explored the use of HA derived from goat bones and teeth, utilizing thermal calcination, and assessed its potential for commercial use through various chemical characterization techniques and biocompatibility tests with different cell lines.
- While HA derived from sheep, goat, and caprine sources shows promise in applications such as antimicrobial activity and wound healing, more research is needed to fully harness these materials for bone graft substitutes and tap into sustainable production methods.