Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.

The NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation against microbial threats, crystals, and danger-associated molecular patterns (DAMPs). Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. Patients with NLRP3 mutations suffer from Cryopyrin-Associated Periodic Syndrome (CAPS) emphasizing the clinical significance of modulating NLRP3.

Physiological responses of the alien macroalga Rugulopteryx okamurae (Phaeophyceae, Heterokontophyta) to changes in nutrients and temperature.

The Asian brown macroalga Rugulopteryx okamurae has invaded the oligotrophic areas of Mediterranean coasts since 2015, with drastic impacts on environmental conditions and socioeconomic activities in coastal areas in Europe. Therefore, it is intriguing how this species is able to grow and expand at the observed rates. In this context, the physiological responses of R.

Impact of the improvement in the etiological diagnosis of community pneumonia.

Background And Objective: Etiological diagnosis of community-acquired pneumonia (CAP) is only reached in 30-40% of cases, which frequently requires keeping empirical antibiotic regimens. The new nucleic acid amplification techniques (NAAT) in respiratory samples raise the possibility of improving this clinical practice. Our objective was to analyze TAANs contribution estimating both their costs and benefits.