Invasive Haemophilus influenzae Disease at a US Children's Hospital in the SARS-CoV-2 Era.

Background: National data previously demonstrated an increase in invasive disease due to non-type b Haemophilus influenzae from the 2000s to the 2010s. Significant shifts in the epidemiology of respiratory pathogens in children have occurred in the post-SARS-CoV-2 era. We examined pediatric invasive H.

Francisco Oller y Ferrer (1758-1831). The surgeon who performed the first smallpox vaccination in a Hispanic American territory.

Balmis arrived on February 9, 1804, in Puerto Rico, the beginning of the American stage of the Philanthropic Expedition of the vaccine that was to begin the campaign to spread the vaccine throughout Hispanic America, in the Philippines, in Macao and Canton and on the island of St. Helena. With this, the surgeon and the expeditionaries under his orders would go down in the annals for heading one of the most transcendental sanitary enterprises carried out in the history of mankind.

Cardiac health, type I collagen, and aging in the mouse model of osteogenesis imperfecta and a cohort of adults with OI.

Osteogenesis imperfecta (OI) is a heritable connective tissue disorder with marked skeletal fragility and increased recognition as a pleiotropic type I collagenopathy. The impact of OI-causing gene variants on cardiac health and lifespan is just beginning to be understood. To begin to investigate cardiac manifestations of OI-causing type I collagen variants, we utilized the osteogenesis imperfecta murine () model to examine survival with increased age, as well as cardiac function and collagen expression at 4 and 18 mo of age.

Management and Outcome of Invasive Clindamycin-Resistant MRSA Community-Associated Infections in Children.

Background: Clindamycin resistance among community-associated methicillin-resistant (CA-MRSA) complicates the management of a challenging infection. Little data exist to guide clinicians in the management of invasive clindamycin-resistant CA-MRSA infections in children and studies using oral regimens such as trimethoprim-sulfamethoxazole (TMP-SMX) and linezolid for treatment of these infections are limited. We sought to reevaluate antibiotic management among invasive CA-MRSA at a tertiary children's hospital.

Effects of prior air pollution exposure on functional recovery after a myocardial infarction.

Air pollution is a major cardiovascular risk factor leading to higher rates of heart failure and myocardial infarction (MI), but its effects on functional recovery after an MI remain unknown. Cardiac rehabilitation is a cornerstone of post-MI care and leads to better performance and quality of life, but its benefits may be hampered in heavily polluted environments. To assess the effect of different pollutants on post-MI rehabilitation, we included 137 post-MI patients from 7 Spanish hospitals that were enrolled in a cardiac rehabilitation program who underwent two cardiopulmonary exercise tests (CPET) within a 12-week period.