Publications by authors named "J Vandenhaute"
Macrophage activation syndrome (MAS) exemplifies a severe cytokine storm disorder with liver inflammation. In the liver, classical natural killer (cNK) cells and liver-resident type 1 innate lymphoid cells (ILC1s) dominate the ILC population. Thus far, research has primarily focused on the corresponding role of cNK cells.
View Article and Find Full Text PDFObjective: We evaluated the public health impact and return on investment of Belgium's pediatric immunization program (PIP) from both healthcare-sector and societal perspectives.
Methods: We developed a decision analytic model for 6 vaccines routinely administered in Belgium for children aged 0-10 years: DTaP-IPV-HepB-Hib, DTaP-IPV, MMR, PCV, rotavirus, and meningococcal type C. We used separate decision trees to model each of the 11 vaccine-preventable pathogens: diphtheria, tetanus, pertussis, poliomyelitis, type b, measles, mumps, rubella, , rotavirus, and meningococcal type C; hepatitis B was excluded because of surveillance limitations.
Article Synopsis
- This study investigates the role and behavior of natural killer (NK) cells in COVID-19 patients, using techniques like flow cytometry and single-cell RNA sequencing, to understand how these immune cells respond during different stages and severity of the disease.* -
- Results show that NK cells from different patient groups (like those in low-care vs. ICU) exhibit distinct activated phenotypes, with early-stage patients showing higher levels of cytotoxic molecules, while later-stage patients display increased levels of specific cytokines (IFN-γ, TNF-α) without typical stimulation.* -
- Key findings also reveal that, although NK cells in severe patients had lower cytotoxic molecules, they still managed to kill target cells effectively, while
Objective: Systemic juvenile idiopathic arthritis (JIA) is a systemic inflammatory disease with childhood onset. Systemic JIA is associated with neutrophilia, including immature granulocytes, potentially driven by the growth factor granulocyte-colony stimulating factor (G-CSF). This study was undertaken to investigate the role of G-CSF in the pathology of systemic JIA.
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