Publications by authors named "J Vancanneyt"
Background: Pancreatic neuroendocrine tumors (pNETs) are rare tumors with heterogeneous outcomes. The aim of our study was to determine the long-term outcome, recurrence patterns, as well as the clinical and pathological factors that impact time-to-recurrence (TTR), recurrence-free survival (RFS), and overall survival (OS) in pNETs treated with curative surgery.
Methods: Data for all patients who underwent radical surgery with curative intent for non-metastatic pNETs were obtained from a prospectively maintained database of the University Hospitals Leuven.
Signet ring cells in the gastrointestinal tract: not always what it seems.
Acta Gastroenterol Belg
October 2024
Article Synopsis
- - Two cases of pseudo-signet ring cells in gastric biopsies were found in otherwise healthy adult males, highlighting a rare nonmalignant condition that can mimic cancer.
- One patient, previously treated for intestinal type gastric adenocarcinoma, underwent surgery before the condition was identified, leading to complications, while the second patient avoided surgery due to early recognition.
- The text emphasizes the importance of careful examination by experienced professionals to prevent misdiagnosis and unnecessary medical procedures when no endoscopic abnormalities are present.
Introduction: Current available systemic therapies for advanced cholangiocarcinoma (CCA) are of limited effectiveness and prognosis is poor. Recently, introduction of next-generation sequencing (NGS) technologies led to a better understanding of the genetic pathophysiology and, consequently, identification of molecular alterations for targeted treatment.
Aim: To determine the proportion of actionable alterations using extensive molecular profiling in a routine diagnostic setting and to study the effect of targeted treatment on disease control.