Publications by authors named "J Van den Akker"

Background: Transfusion reactions occur at an estimated incidence of 2 per 1.000 transfused products. Anaphylactic transfusion reactions are rarer, and seen in 1 per 10.

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Article Synopsis
  • * Researchers looked at studies about the germs found in the lungs of patients with serious AECOPD. They found specific harmful bacteria in a lot of these patients, which could make their condition worse.
  • * Although some treatments worked well to get rid of these harmful bacteria, some were hard to eliminate because they resisted multiple types of medicine. More research is needed to understand how all the germs in the lungs (including viruses) affect patient outcomes.
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Background: The dynamics of Staphylococcus aureus in patients and the hospital environment are relatively unknown. We studied these dynamics in a tertiary care hospital in the Netherlands.

Methods: Nasal samples were taken from adult patients at admission and discharge.

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Purpose: Pulmonary emboli (PE) contribute substantially to coronavirus disease 2019 (COVID-19) related mortality and morbidity. Immune cell-mediated hyperinflammation drives the procoagulant state in COVID-19 patients, resulting in immunothrombosis. To study the role of peripheral blood mononuclear cells (PBMC) in the procoagulant state of COVID-19 patients, we performed a functional bioassay and related outcomes to the occurrence of PE.

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 Fibrinogen variants as a result of alternative messenger RNA splicing or protein degradation can affect fibrin(ogen) functions. The levels of these variants might be altered during coronavirus disease 2019 (COVID-19), potentially affecting disease severity or the thrombosis risk.  To investigate the levels of fibrinogen variants in plasma of patients with COVID-19.

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