Publications by authors named "J Van Vleet"
The GM2 gangliosidoses, Tay-Sachs disease and Sandhoff disease, are devastating neurodegenerative disorders caused by β-hexosaminidase A (HexA) deficiency. In the Sandhoff disease mouse model, rescue potential was severely reduced when HexA was introduced after disease onset. Here, we assess the effect of recombinant HexA and HexD3, a newly engineered mimetic of HexA optimized for the treatment of Tay-Sachs disease and Sandhoff disease.
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- * A shortage of skilled surgeons for lymphedema surgeries may hinder patient access, but robotic systems could help less experienced surgeons improve their skills and reduce physical strain.
- * Continued research and advancements in robotic technology, such as the Symani system, are vital for enhancing surgical techniques and addressing the growing challenges related to lymphedema treatment.
Etherified Carboxymethylcellulose Matrix (eCMC) is a revolutionary application of carboxymethylcellulose (CMC) in wound care, known for its potential in hemostasis and tissue regeneration. This study aims to investigate the mechanism of eCMC in tissue healing by establishing a rat burn model and administering eCMC as a treatment. The objective is to analyze cytokines and inflammatory mediators using a Cytokine Array and histochemical staining to understand the effects of eCMC on tissue regeneration.
View Article and Find Full Text PDFPurpose Of Review: With the improvement in device technology and delivery methods of inhaled medications, along with development of novel compounds and recognition of the importance of personalized approach in the management of chronic airway diseases, nebulizers have not only maintained their place in the treatment hierarchy of airway disease but have also proven a vital platform for the development of new classes of drugs.
Recent Findings: This short review explores recent advances in nebulized drug delivery in chronic obstructive pulmonary disease and other chronic airway diseases, emphasizing the progress in nebulizer technology, physiologic advantages of nebulized drug delivery and the high versatility of currently available and developing nebulizer-delivered pharmacotherapies.
Summary: Versatility and efficiency of nebulizers allows for a broad spectrum of existing and novel therapies to be clinically studied, facilitating the progress in phenotype-targeted pharmacotherapies in the management of chronic airway diseases.
Article Synopsis
- * This study investigates the accumulation of GM2/GA2 gangliosides and other metabolites in feline (Sandhoff) and ovine (Tay-Sachs) models, finding that Sandhoff cats accumulate more of these substances, particularly in their brains.
- * A new LC/MS assay was developed to track glycan metabolites over time, revealing significant increases in these compounds in Sandhoff cats, which could help assess disease severity and treatment effectiveness as they age.