Publications by authors named "J Van Reempts"
Article Synopsis
- Inflammatory responses play a significant role in causing damage after traumatic brain injury (TBI).
- Researchers studied the expression of key proinflammatory molecules in rats following closed head injury (CHI), observing a spike in certain cytokine levels shortly after the trauma.
- Key findings indicated that while proinflammatory molecules (IL-1beta, IL-6, TNF-alpha) increased rapidly within hours after injury, their levels dropped back toward baseline by 24 hours, suggesting a complex healing process that could impact areas beyond the initial injury site.
The present study validates a method for continuous measurement of intracranial pressure (ICP) in freely moving rats after experimental induction of impact-acceleration injury. Rats subjected to either mild or moderate trauma were individually placed in a Bas-Ratturn system, equipped with a sensor that synchronously turns the cage in response to the locomotor activity of the animal. In this way correct probe positioning is permanently assured and damage due to coiling is avoided.
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- Unilateral intracarotid injection of contrast agents can significantly disrupt the blood-brain barrier in rats, resulting in vasogenic edema on the same side (ipsilateral hemisphere).
- Administering ultrasound contrast agents after mild traumatic brain injury greatly increases mortality and leakage of fluids.
- This method of direct contrast agent administration highlights edema-related issues and can worsen outcomes in studies involving neurotrauma.
Cerebral blood flow assessment with indocyanine green bolus transit detection by near-infrared spectroscopy in the rat.
Comp Biochem Physiol A Mol Integr Physiol
May 2002
In this study we evaluated the feasibility of measuring cerebral blood flow in rats by monitoring the transit of an indocyanine green bolus through the brain with multiwavelength near-infrared spectroscopy. Different volumes of a 1 mg/ml indocyanine green solution (5, 15, 25, 50 microl) were injected intravenously in the search for an optimal dose. Clear transit curves were obtained with all doses and a blood flow index could easily be determined.
View Article and Find Full Text PDFIn this study, near-infrared spectroscopy was applied to examine whether cytochrome oxidase in the rat brain is inhibited by nitric oxide in vivo. During normoxia, intravenous N(G)-nitro-L-arginine methyl ester (L-NAME) administration significantly decreased the cerebral saturation of hemoglobin with oxygen but did not alter the cytochrome oxidase redox state. Anoxia significantly reduced the cytochrome oxidase.
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