Publications by authors named "J Van Gool"
Article Synopsis
- Hypocretin deficiency leads to type 1 narcolepsy, which is associated with excessive daytime sleepiness and a high prevalence of overweight and obesity in patients.
- A study compared energy expenditure in ten males with narcolepsy to nine healthy controls using respiration chamber calorimetry and doubly labelled water.
- Results showed no significant differences in energy expenditure or physical activity between the two groups, suggesting that weight gain in narcolepsy might be influenced by factors other than metabolism, such as dietary habits.
Article Synopsis
- * Researchers analyzed data from over 1500 patients and found that women reported higher sleepiness on the Epworth Sleepiness Scale compared to men, with specific age-related trends observed in different patient groups.
- * Notably, in women with narcoleptic conditions, an increase in daytime sleepiness was linked to age, while weight gain appeared later, suggesting a complex relationship that warrants further research for targeted treatment approaches.
Sleep Med Rev
December 2024
Article Synopsis
- * There's a possibility that an autoimmune process is involved, but tests for specific autoantibodies and T-cells haven't provided clear answers; other factors, like reduced hormone production in the brain, are also being considered.
- * Currently, there is no cure for NT1, and treatment focuses on managing symptoms; however, new hypocretin receptor agonists are showing promise in clinical trials, highlighting the need for better understanding and early diagnosis to improve treatment outcomes, especially in children
Article Synopsis
- * Researchers reviewed medical records from 290 individuals with NT1 and 115 with NT2 or IH to analyze immunological events, such as infections and vaccinations, that occurred before the onset of hypersomnolence.
- * Results indicate that NT1 shows a stronger association with flu infections and vaccinations, whereas NT2 and IH are linked to other viral infections; the study highlights the need for further investigation into these distinct immunological triggers.
