Publications by authors named "J Van Dorpe"
Article Synopsis
- Aberrant embryo implantation and placentation can lead to serious pregnancy complications like preeclampsia, and current risk identification methods are not very accurate.
- The ExPECT study aims to validate a cell-free DNA methylation strategy to diagnose preeclampsia early and identify high-risk pregnancies by analyzing blood samples over time.
- Results showed distinct methylation patterns between healthy and affected pregnancies, with significant differences detectable as early as 12 weeks, leading to the development of promising classification models for diagnosis and prediction.
Pulmonary involvement in transthyretin cardiac amyloidosis: a case report.
Eur Heart J Case Rep
November 2024
Background: Amyloidosis is a systemic disorder characterized by the deposition of misfolded proteins in various organs. While cardiac transthyretin amyloidosis (ATTR) is well-recognized, pulmonary involvement is rare and often overlooked in clinical practice.
Case Summary: We present a case of severe, and ultimately fatal, cardiac and pulmonary ATTR amyloidosis in a 67-year-old male.
About 5% of patients with cutaneous squamous cell carcinoma (cSCC) have a poor prognosis which is associated with a loss of tumor differentiation, invasion and metastasis, all of which are linked to the process of epithelial-to-mesenchymal plasticity (EMP). Here, we showed that the EMP-associated transcription factor ZEB2 drives cSCC heterogeneity which resembles biphasic carcinosarcoma-like tumors. Single cell RNA sequencing revealed distinct subpopulations ranging from fully epithelial (E) to intermediate (EM) to fully mesenchymal (M), associated with the gradual loss of cell surface markers EPCAM, CDH1, ITGB4, and CD200.
View Article and Find Full Text PDFThe diagnosis of lymphomas is challenging due to their diverse histological presentations and clinical manifestations. There is a need for inexpensive tools that require minimal expertise and are accessible for routine laboratories. Contrastingly, current conventional diagnostic methods are often found only in specialized environments.
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