Predicting the development of hemophilic arthropathy in patients with hemophilia based on patient age: a retrospective single-center database study.

Background: Patients with hemophilia (PWH) develop hemophilic arthropathy of the major joints due to recurrent hemarthrosis. This study retrospectively estimated the age at which PWH may expect to develop hemophilic arthropathy and undergo joint replacement surgery.

Research Design And Methods: Using retrospective data from PWH at a Czech orthopedic center, Kaplan Meier analyses were used to estimate the cumulative proportions of patients with hemophilic arthropathy and undergoing joint replacement surgery as a function of age.

Thermal degradation of Affinisol HPMC: Optimum Processing Temperatures for Hot Melt Extrusion and 3D Printing.

Purpose: Affinisol HPMC HME is a new popular form of hypromellose specifically designed for the hot melt extrusion and 3D printing of pharmaceutical products. However, reports of its thermal stability include only data obtained under inert N atmosphere, which is not consistent with the common pharmaceutical practice. Therefore, detailed investigation of its real-life thermal stability in air is paramount for identification of potential risks and limitations during its high-temperature processing.

Investigation of Brønsted acidity in zeolites through adsorbates with diverse proton affinities.

Understanding the adsorption behavior of base probes in aluminosilicates and its relationship to the intrinsic acidity of Brønsted acid sites (BAS) is essential for the catalytic applications of these materials. In this study, we investigated the adsorption properties of base probe molecules with varying proton affinities (acetonitrile, acetone, formamide, and ammonia) within six different aluminosilicate frameworks (FAU, CHA, IFR, MOR, FER, and TON). An important objective was to propose a robust criterion for evaluating the intrinsic BAS acidity (i.

A decrease in serum 1,25(OH)D after elective hip replacement and during bone healing is associated with changes in serum iron and plasma FGF23.

Objective: Although calcitriol is essential for bone healing, its serum concentrations are low after hip surgery, and they continue to decline during bone healing. This study aimed to test the hypothesis of an association of changes in calcitriol production with the status of fibroblast growth factor 23 (FGF23) and iron deficiency after elective hip replacement for coxarthrosis.

Methods: In this prospective study, we measured the biomarkers of 17 patients undergoing elective hip replacement on admission, on the first day after surgery, and at the regular check-up after 48 ± 8 days.

Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing.

Objective: To assess the decrease in serum calcitriol concentrations after hip fracture.

Methods: Serum concentrations of calcitriol, 25(OH)D, parathyroid hormone (PTH), directly measured free 25(OH)D, and indices of bone formation were measured in elderly patients with hip fracture (HF) and patients with elective hip replacement (EHR) at admission and after 7 weeks.

Results: A total of 45 patients with HF and 17 patients with EHR completed this prospective study.