Publications by authors named "J Vachtenheim"
Article Synopsis
- - Acute cellular rejection (ACR) is common after lung transplants and can lead to chronic lung problems and affect survival rates; diagnosing it can be tricky due to inconsistent interpretations among pathologists.
- - This study explored the use of immunohistochemistry to identify specific markers (like PD-L1 and PECAM-1) in lung tissue samples from lung transplant patients to improve ACR diagnosis.
- - Results showed that PD-L1 levels were higher in patients with ACR, indicating an immune response suppression effort, and there were notable differences in PECAM-1 levels, highlighting these markers’ potential usefulness for detecting ACR.
Histologic evaluation of allograft biopsies after lung transplantation has several limitations, suggesting that molecular assessment using tissue transcriptomics could improve biopsy interpretation. This single-center, retrospective cohort study evaluated discrepancies between the histology of transbronchial biopsies (TBBs) with no rejection (NR) and T-cell mediated rejection (TCMR) by molecular diagnosis. The accuracy of diagnosis was assessed based on response to treatment.
View Article and Find Full Text PDFIntroduction: Compared with traditional static ice storage, controlled hypothermic storage (CHS) at 4-10°C may attenuate cold-induced lung injury between procurement and implantation. In this study, we describe the first European lung transplant (LTx) experience with a portable CHS device.
Methods: A prospective observational study was conducted of all consecutively performed LTx following CHS (11 November 2022 and 31 January 2024) at two European high-volume centers.
Extracorporeal membrane oxygenation (ECMO) is frequently used during lung transplantation. Unfractionated heparin (UFH) is mainly used as part of ECMO support for anticoagulation. One of the most common perioperative complications is bleeding, which high-dose UFH can aggravate.
View Article and Find Full Text PDFIntratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that high-grade serous ovarian carcinoma (HGSOC) contains distinct immune aggregates with varying degrees of organization and maturation. Specifically, mature TLSs (mTLS) as forming only in 16% of HGSOCs with relatively elevated tumor mutational burden (TMB) are associated with an increased intratumoral density of CD8 effector T (T) cells and TIM3PD1, hence poorly immune checkpoint inhibitor (ICI)-sensitive, CD8 T cells.
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