Publications by authors named "J V Zappia"
Survival Outcomes by Race Following Surgical Treatment for Upper Tract Urothelial Carcinoma.
Clin Genitourin Cancer
December 2024
Objective: Discrepancies in survival outcomes of various genitourinary tract malignancies have been documented across different racial and ethnic groups. Here we sought to examine long-term survival outcomes of patients with upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU) when stratified by race.
Methods: A multicenter retrospective analysis using the ROBUUST (ROBotic surgery for Upper tract Urothelial cancer Study) registry identified patients undergoing RNU for UTUC between 2015 and 2022 at 12 centers across the United States, Europe, and Asia.
Purpose: Determine whether adult cochlear implant users with radiographic superior semicircular canal dehiscence experience clinically significant differences in audiological outcomes when compared to cochlear implant users with normal temporal bone anatomy.
Materials And Methods: Retrospective, single institution review. Adult, post-lingual deaf patients implanted between 2010 and 2020.
Article Synopsis
- The study reviews over 32 years of outcomes for ileal ureter replacement, highlighting it as a viable reconstructive option for challenging ureteral strictures.
- A retrospective analysis of 158 patients showed that most had unilateral procedures, with many having existing kidney issues, but overall, many maintained good renal function post-surgery.
- Despite some long-term complications, the findings suggest that ileal ureter creation is a safe and effective treatment for complex ureter injuries, with a majority experiencing minimal complications.
"Persistent organic pollutants (POPs)" have a plethora of deleterious effects on humans and the environment due to their bioaccumulative, persistent, and mimicking properties. Individually, each of these chemicals has been tested and its effects measured, however they are rather found as parts of complex mixtures of which we do not fully grasp the extent of their potential consequences. Here we studied the effects of realistic, environmentally relevant mixtures of 29 POPs on cartilage and bone development using zebrafish as a model species.
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- Zebrafish are being extensively used to study bone development and diseases, emphasizing the need to understand how osteoblasts differentiate and function.
- Researchers isolated specific osteoblast subpopulations from young zebrafish to examine their unique genetic and signaling characteristics.
- Mutations in genes related to extracellular matrix proteins showcased significant alterations in skeletal structure and mineral density in zebrafish, underlining the proteins' crucial role in bone development and maintenance.