Publications by authors named "J V U S Chakradhar"
Article Synopsis
- Favipiravir is typically taken orally, but this study explores its effectiveness when delivered directly to the lungs via inhalation to achieve higher concentrations at the site of infection and bypass liver metabolism.
- Researchers created a dry powder inhalation formulation and tested it on mice, comparing the inhaled doses to standard oral doses to measure drug concentration in the blood and lungs.
- Results showed that inhaling a much smaller dose of favipiravir (1/25th of the oral dose) resulted in higher drug levels in the lungs and similar effectiveness in the blood, supporting the potential for a targeted method of treating respiratory viral infections.
Combinatorial delivery of Doxorubicin (DOX) and Baicalein (BAC) has a potential to improve breast cancer treatment by mitigating the cardiotoxicity induced by DOX. The nanoformulation has been optimized and subjected to pharmacokinetic studies using LC-MS/MS. Nanoformulation bearing DOX and BAC was optimized using quality by design approach and method validation was done following USFDA guidelines.
View Article and Find Full Text PDFA HPLC method was developed and validated for the novel combination of rutin (RN) and donepezil (DNP). RN and DNP were simultaneously eluted through a C18 column (Ø 150 × 4.6 mm) with a 60:40 v/v ratio of 0.
View Article and Find Full Text PDFMycobacterium tuberculosis (Mtb) infection leads to upregulation of Suppressors of Cytokine signaling (SOCS) expression in host macrophages (Mϕ). SOCS proteins inhibit cytokine signaling by negatively regulating JAK/STAT. We investigated this host-pathogen dialectic at the level of transcription.
View Article and Find Full Text PDF