Trochlear Morphological Changes in Skeletally Immature Patients Across Consecutive MRI Studies.

Background: Trochlear dysplasia is a consistent risk factor for recurrent patellofemoral instability (PFI), but there is limited understanding of how the trochlea develops during growth. The aim of this study was to evaluate serial magnetic resonance imaging (MRI) studies performed in skeletally immature patients with and without PFI to characterize changes in trochlear anatomy over time.

Hypothesis: PFI leads to progressive worsening of trochlear dysplasia over time.

Radiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations.

Background And Purpose: Timely reporting of CTA exams impacts management of acute vascular pathology such as large vessel occlusions, arterial dissection, and ruptured aneurysm as well as a variety of acute non-vascular pathologies. In this study, we examine potential modifiable factors impacting the timeliness of CTA reporting performed in stroke code activations.

Materials And Methods: Observational study of stroke code CTA head and neck exams performed at a single health system (3 emergency departments, 1550 inpatient beds) over four years (1/1/2019-12/31/2023).

Femur osteoid osteoma in children: are there location-dependent differences in MRI findings?

Background: Osteoid osteomas are most commonly found in the femur and preferentially affect the pediatric population. Magnetic resonance imaging (MRI) findings of femoral osteoid osteomas are not well described.

Objective: To systematically characterize pretreatment MRI findings of clinically confirmed femur osteoid osteomas in children and determine location-dependent differences.

Biochemical and physiological characterization of midgut chymotrypsin.

The mosquito is a vector of dengue, Zika, and chikungunya. The mosquito's reliance on blood facilitates the transmission of these viral pathogens to humans. Digestion of blood proteins depends on the biphasic expression of serine proteases, with trypsin-like activity contributing to most of the activity in the midgut.

Combinatorial Nanoparticle-Bound ssDNA Oligonucleotide Library Synthesized by Split-and-Pool Synthesis.

Synthetic ssDNA oligonucleotides hold great potential for various applications, including DNA aptamers, DNA digital data storage, DNA origami, and synthetic genomes. In these contexts, precise control over the synthesis of the ssDNA strands is essential for generating combinatorial sequences with user-defined parameters. Desired features for creating synthetic DNA oligonucleotides include easy manipulation of DNA strands, effective detection of unique DNA sequences, and a straightforward mechanism for strand elongation and termination.