Assessing time series correlation significance: A parametric approach with application to physiological signals.

Correlation coefficients play a pivotal role in quantifying linear relationships between random variables. Yet, their application to time series data is very challenging due to temporal dependencies. This paper introduces a novel approach to estimate the statistical significance of correlation coefficients in time series data, addressing the limitations of traditional methods based on the concept of effective degrees of freedom (or effective sample size, ESS).

Efficient Generation of Knock-Out Sheep by Electroporation of CRISPR-Cas9 Ribonucleoprotein Complex with Dual-sgRNAs.

In mice, naturally occurring and induced mutations in the suppressor of cytokine signaling-2 () gene are associated with a high growth phenotype characterized by rapid post-weaning weight gain and 30-50% heavier mature body weight. In this work, we demonstrate an electroporation-based method of producing knock-out (KO) sheep. Electroporation of dual-guide CRISPR-Cas9 ribonucleoprotein complexes targeting was performed 6 h post-fertilization in sheep zygotes.

Comparing Differences and Relationships Between Traditional and Resisted Sprints in Elite Youth Rugby Backs and Forwards.

Purpose: We tested the differences in maximum strength and various parameters of sprint performance between youth backs and forwards. Additionally, we examined the associations among various strength-sprint measures, as well as between unresisted and heavy resisted sprints.

Methods: Thirty-two youth rugby players were assessed at the beginning of the season with the following tests: unresisted and resisted (50% body mass) 30-m sprints and 1-repetition maximum (1RM) in the squat exercise.

Environmental fungi target thiol homeostasis to compete with Mycobacterium tuberculosis.

Mycobacterial species in nature are found in abundance in sphagnum peat bogs where they compete for nutrients with a variety of microorganisms including fungi. We screened a collection of fungi isolated from sphagnum bogs by co-culture with Mycobacterium tuberculosis (Mtb) to look for inducible expression of antitubercular agents and identified 5 fungi that produced cidal antitubercular agents upon exposure to live Mtb. Whole genome sequencing of these fungi followed by fungal RNAseq after Mtb exposure allowed us to identify biosynthetic gene clusters induced by co-culture.

De novo whole-genome assembly and annotation of Coffea arabica var. Geisha, a high-quality coffee variety from the primary origin of coffee.

Geisha coffee is recognized for its unique aromas and flavors and, accordingly, has achieved the highest prices in the specialty coffee markets. We report the development of a chromosome-level, well-annotated, genome assembly of Coffea arabica var. Geisha.