Publications by authors named "J V Kratz"
Background And Objectives: Standard treatment of patients with stage II/III esophageal or gastroesophageal junction (E/GEJ) cancer involves neoadjuvant chemoradiation (nCRT), resection, and immunotherapy. Our trial evaluated the addition of perioperative avelumab to standard treatments.
Methods: Patients with resectable E/GEJ cancers received avelumab with nCRT and adjuvant avelumab after resection.
Development and validation of ultra-performance liquid chromatography tandem mass spectrometry methods for the quantitative analysis of the antiparasitic drug DNDI-6148 in human plasma and various mouse biomatrices.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Article Synopsis
- * A validated ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method was developed to accurately measure DNDI-6148 levels in various biological samples, following international guidelines on bioanalytical methods.
- * The study found that collagenase A-based enzymatic homogenization extracted DNDI-6148 2.9 times more effectively from mouse skin compared to traditional methods, with consistent accuracy and recovery rates across different biomatrices
To optimize their fitness, cells face the crucial task of efficiently responding to various stresses. This necessitates striking a balance between conserving resources for survival and allocating resources for growth and division. The fundamental principles governing these tradeoffs is an outstanding challenge in the physics of living systems.
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- * Epidemiological studies indicate higher incidence rates of BTC in South and Central Asia, particularly for intrahepatic cholangiocarcinoma (iCCA), compared to much lower rates in Europe and the U.S.
- * The review also highlights the varying frequency of MDM2 gene amplifications in BTC subtypes, with gallbladder cancer showing the highest amplification rates, emphasizing the importance of standardized assessment in BTC research.