Publications by authors named "J V Hennessey"
Article Synopsis
- Catheter ablation for ventricular tachycardia (VT) currently uses isochronal late activation mapping (ILAM), which helps identify isthmus regions by categorizing activation times into a limited number of isochrones.
- This study evaluates whether the methods used in ILAM are the most effective by testing various numbers of isochrones and exploring continuous metrics that improve isthmus detection.
- Results showed that increasing the number of isochrones or using continuous metrics significantly enhanced the identification precision of isthmus regions, indicating that current practices can be optimized for better outcomes in VT ablation.
Article Synopsis
- Previous research on professional basketball athletes has mostly focused on male athletes and female echocardiography, resulting in a lack of ECG data specific to female athletes.
- The study aimed to create reference ECG data for female professional basketball players, collecting data during mandatory preseason screenings between April and May 2022 and analyzing it from February to July 2023.
- Of the 173 women analyzed, 78.6% showed training-related ECG changes, while 4.6% had abnormal findings, with a significant number also displaying left ventricular adaptations linked to athletic remodeling.
In 1909, Italian zoologist Daniele Rosa (1857-1944) proposed a radical new evolutionary theory: hologenesis, or simultaneous, pan-terrestrial creation and evolution driven primarily by internal factors. Hologenesis was widely ignored or rejected outside Italy, but Swiss-French anthropologist George Montandon (1879-1944) eagerly embraced and developed the theory. An ambitious careerist, Montandon's deep investment in an obscure and unpopular theory is puzzling.
View Article and Find Full Text PDFSerotonergic psychedelics possess considerable therapeutic potential. Although 5-HT receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5-HT-Gq/11 and β-arrestin2 transducers, making their respective roles unclear. To elucidate this, we develop a series of 5-HT-selective ligands with varying Gq efficacies, including β-arrestin-biased ligands.
View Article and Find Full Text PDFSerotonergic psychedelics possess considerable therapeutic potential. Although 5-HT receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5-HT-Gq/11 and β-arrestin2 signaling, making their respective roles unclear. To elucidate this, we developed a series of 5-HT-selective ligands with varying Gq efficacies, including β-arrestin-biased ligands.
View Article and Find Full Text PDF