Publications by authors named "J V Garcia-Lario"
This study aimed to investigate the effects 24 weeks of supervised exercise training at different intensities on S-Klotho and 25-hydroxyvitamin D plasma levels in young adults. This report was based on a secondary analysis from the ACTIBATE single-center unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129).
View Article and Find Full Text PDFBackground: Perfluoroalkyl substances (PFAS) and phthalates are synthetic chemicals widely used in various types of consumer products. There is epidemiological and experimental evidence that PFAS and phthalates may alter thyroid hormone levels; however, studies in children and adolescents are limited.
Aim: To investigate the association of exposure to PFAS and phthalate with serum levels of thyroid hormones in European adolescents.
Article Synopsis
- PFAS exposure can affect human reproductive functions, influencing puberty timing and hormone levels, though the exact mechanisms remain unclear.
- The study analyzed serum samples from 733 teenagers in Belgium, Slovakia, and Spain, measuring various PFAS compounds and reproductive hormones using advanced lab techniques.
- Findings revealed sex-specific associations, with PFAS linked to higher testosterone levels in girls and lower follicle-stimulating hormone levels in boys, highlighting potential adverse effects on the reproductive axis due to PFAS exposure.
Objectives: The estimates of biological variation (BV) have traditionally been determined using direct methods, which present limitations. In response to this issue, two papers have been published addressing these limitations by employing indirect methods. Here, we present a new procedure, based on indirect methods that analyses data collected within a multicenter pilot study.
View Article and Find Full Text PDFCirculating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults.
J Physiol Biochem
August 2022
Thyroid dysfunction is associated with classic cardiometabolic risk factors in humans. However, this relationship remains unclear in young euthyroid adults. The present work examines the associations of circulating thyroid hormones (THs) and thyroid-stimulating hormone (TSH) concentrations with body composition and cardiometabolic risk factors in young euthyroid adults.
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