Publications by authors named "J V Cobo"
Human lactate dehydrogenase A (LDHA) is a homotetrameric isozyme involved in the conversion of glyoxylate into oxalate in the cytosol of liver cells (hepatocytes) and partially responsible for the overproduction of oxalate in patients with the rare disease called primary hyperoxaluria (PH). Recently, LDHA inhibition has been validated as a safe therapeutic method to try to control the PH disease. Stiripentol (STP) is an approved drug used in the treatment of seizures associated with Dravet's syndrome (a severe form of epilepsy in infancy) which, in addition, has been drawing interest in recent years also for potentially treating PH, due to its LDHA inhibitory activity.
View Article and Find Full Text PDFLymphocyte-derived and lipoprotein-derived inflammatory ratios as biomarkers in bipolar disorder type I: Characteristics, predictive values, and influence of current psychopharmacological treatments.
Psychoneuroendocrinology
January 2025
Purpose Of This Research: The purpose of this research was to investigate peripheral inflammation by analyzing lymphocyte and lipoprotein-derived inflammatory ratios in patients with bipolar disorder type I (BD-I) and healthy controls (HCs), considering mood stabilizer drug treatments, sex and clinical trajectories.
Methods: This was a cross-sectional case-control study of BD-I patients (n=252) and healthy controls (n=62). We investigated peripheral inflammation biomarkers through blood count values (CBCs), lipoproteins and a complex panel of inflammatory ratios, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-HDL ratio (NHR), monocyte-to-HDL ratio (MHR), platelet-to-HDL ratio (PHR) and lymphocyte-to-HDL ratio (LHR).
Article Synopsis
- * Researchers designed a novel family of compounds using virtual docking to enhance the inhibition of hLDHA through a specific synthetic pathway involving ethyl pyrimidine-quinolinecarboxylate derivatives.
- * Out of the synthesized inhibitors, 13 demonstrated potent effects with IC values lower than 5 μM, and selectivity testing showed that some were selective for the hLDHA isoform over hLDHB, marking them as potential therapeutic agents.
Objectives: The prognosis of bone and joint infections (BJI) caused by Gram-negative bacilli (GNB) worsens significantly in the face of fluoroquinolone-resistance. In this setting, scarce pre-clinical and clinical reports suggest that intravenous beta-lactams plus colistin may improve outcome. Our aim was to assess the efficacy and safety of this treatment in a well-characterized prospective cohort.
View Article and Find Full Text PDFArticle Synopsis
- Older people (80 years and up) are at risk for getting Clostridioides difficile infection (CDI) more often and it's usually more severe when they do.
- A study looked at patients with CDI from 2021 to 2022 to see how age affected recurrence and survival after treatment.
- They found that older patients had a higher chance of dying from CDI, even though the recurrence rates were similar for both age groups.