Publications by authors named "J V Castello"

Article Synopsis
  • The MOUD Hub is a new, user-friendly website aimed at improving access to medications for opioid use disorder (MOUD) by providing reliable information and resources.
  • The study will assess the safety, acceptability, and feasibility of the Hub through focus groups with individuals who have lived experience with opioid use disorder and potential users.
  • The website is set to launch in January 2025, with plans to promote it on Google and Reddit to reach a broader audience and analyze user engagement.
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Introduction: Intracerebral hemorrhage (ICH) is attributable to cerebral small vessel disease (cSVD), which includes cerebral amyloid angiopathy (CAA) and hypertensive-cSVD (HTN-cSVD). HTN-cSVD includes patients with strictly deep ICH/microbleeds and mixed location ICH/microbleeds, the latter representing a more severe form of HTN-cSVD. We test the hypothesis that more severe forms of HTN-cSVD are related to worse hypertension control in long-term follow-up after ICH.

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Background: Cerebral Amyloid Angiopathy (CAA) disease course is highly variable even in hereditary forms. Sex may be a possible modifying factor. We investigated biological sex differences in clinical disease course and magnetic resonance imaging-markers in sporadic (sCAA) and Dutch-type hereditary CAA (D-CAA).

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Background: Blood pressure (BP) control represents a crucial intervention to improve long-term outcomes following spontaneous intracerebral hemorrhage (ICH). However, fewer than half of ICH survivors achieve target treatment goals. ICH survivors are also at very high risk for poststroke depression, which may contribute to inadequate BP control.

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