Anthropometric Indices as a Predictive Screening Tool for Hypertension among Young Indian Adults.

Background: High blood pressure (BP) is increasing at an alarming rate in India and is the leading cause of cardiovascular disease. Increasing obesity is one of the risk factors for the increasing trend in hypertension among young adults.

Objectives: This study aimed to assess the comparative abilities of anthropometric indices of general and central obesity in predicting hypertension among apparently healthy young adults.

SOX17-Associated Pulmonary Hypertension in Children: A Distinct Developmental and Clinical Syndrome.

Objective: To characterize clinical, hemodynamic, imaging, and pathologic findings in children with pulmonary arterial hypertension (PAH) and variants in SRY-box transcription factor 17 (SOX17), a novel risk gene linked to heritable and congenital heart disease-associated PAH.

Study Design: We assembled a multi-institutional cohort of children with PAH and SOX17 variants enrolled in the Pediatric Pulmonary Hypertension Network (PPHNet) and other registries. Subjects were identified through exome and PAH gene panel sequencing.

Optimum radiation dose for palliation in head and neck squamous cell carcinoma (OpRAH) - A phase 3 randomized controlled trial.

Purpose: Radiotherapy is frequently employed for palliative treatment in locally advanced head and neck squamous cell carcinoma (HNSCC) but radiation dose fractionation regimens are not well-defined. We designed this phase 3 randomized controlled trial to compare two weekly hypo fractionated regimes and study the effect on progression-free survival (PFS) in this subset of patients.

Materials And Methods: Non-metastatic locally advanced HNSCC patients (n = 305) who were not suitable for curative treatment were randomized to Arm A (20 Gy/5#/5 days) and Arm B (30 Gy/5#/5 days).

Safety and immunogenicity of a pentavalent meningococcal conjugate vaccine versus a quadrivalent meningococcal conjugate vaccine in adults in India: an observer-blind, randomised, active-controlled, phase 2/3 study.

Background: Meningococcal disease remains an important public health problem globally. We assessed the non-inferiority and the lot-to-lot consistency of a pentavalent meningococcal ACYWX conjugate vaccine (NmCV-5; Serum Institute of India, Pune, India) versus a quadrivalent meningococcal ACWY conjugate vaccine (MenACWY-D) in healthy adults.

Methods: In this observer-blind, randomised, active-controlled, phase 2/3 study, healthy adults aged 18-85 years were recruited from nine hospitals across seven cities in India.

Efficacy of the Coronoid Notch and Occlusal Plane As Predictable Landmarks for Determining the Medial Cut Height in Bilateral Sagittal Split Osteotomy: A Split-Mouth Observational Study.

Aim: This split-mouth observational study was conducted to assess the reliability and safety of using the coronoid notch and occlusal plane as landmarks to aid surgeons during bilateral sagittal split osteotomy (BSSO).

Materials And Methods: Thirteen patients between the ages of 18 and 30 years, with class II and class III mandibular skeletal malocclusion requiring BSSO, were randomly selected and assigned to each of the study and control groups. A split-mouth study was chosen to conduct this research.