Publications by authors named "J Upchurch"
Background And Aims: Colorectal cancer (CRC) polygenic risk scores (PRS) may help personalize CRC prevention strategies. We investigated whether an existing PRS was associated with advanced neoplasia (AN) in a population undergoing screening and follow-up colonoscopy.
Methods: We evaluated 10-year outcomes in the Cooperative Studies Program #380 screening colonoscopy cohort, which includes a biorepository of selected individuals with baseline AN (defined as CRC or adenoma ≥10 mm or villous histology, or high-grade dysplasia) and matched individuals without AN.
Article Synopsis
- Gulf War veterans are facing various health issues, with many reporting a chronic condition known as Gulf War illness (GWI) as they reach middle age and older adulthood.
- The study aims to analyze the accumulation of health deficits among veterans with Severe GWI (SGWI+) compared to those without (SGWI-), seeking to understand the connection between unexplained illnesses and aging.
- Results indicate that veterans with SGWI+ tend to experience significantly more years with severe health deficits, highlighting a 13-fold increase in the likelihood of accumulating substantial health issues, particularly among middle-aged veterans.
To examine whether severe Gulf War illness (SGWI) case status was associated with longitudinal multimorbidity patterns. Participants were users of the Veteran Health Administration Health Care System drawn from the Gulf War Era Cohort and Biorepository ( = 840). Longitudinal measures of multimorbidity were constructed using (1) electronic health records (Charlson Comorbidity Index; Elixhauser; and Veterans Affairs Frailty Index) from 10/1/1999 to 6/30/2023 and (2) self-reported medical conditions (Deficit Accumulation Index) since the war until the survey date.
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- Gulf War illness (GWI) is a sickness that affects veterans who served in the Gulf War and is believed to be caused by harmful substances they were exposed to during their deployment.
- Many veterans also experience posttraumatic stress disorder (PTSD), which may influence the symptoms of GWI.
- A study showed that veterans with both GWI and PTSD reported more military exposures compared to those without PTSD, highlighting how both GWI and PTSD can be connected to their experiences during the war.
Background: Gulf War Illness (GWI) is a chronic, multi-symptom disorder affecting 25%-32% of Gulf War veterans. Veterans with GWI disproportionately suffer from gastrointestinal (GI) disorders. Given the increasing evidence supporting a gut-brain axis, we explore the relationship between post-traumatic stress disorder (PTSD), GWI, and self-reported GI disorders among GW veterans.
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