[Excretion of gamma-glutamyltranspeptidase in urine of patients treated with gentamicin].

The excretion of gamma-glutamyltranspeptidase (GGTP) in 240 hour urine was studied in 21 patients treated with gentamicin for bronchopneumonia. The treatment was conducted for a period of 8-10 days using gentamicin in a dose of 2-5 mg/kg body weight daily. The studies of GGTP urine excretion were carried out on the first and the last day of the treatment, and on the 10th day after completion of treatment.

[Activity of gamma-glutamyltranspeptidase in serum and urine of patients with polycystic renal disease and hepatic cystic disease].

The determination of gamma-glutamyltranspeptidase activity was carried out by the Rosalka et al. method in the serum and urine in the control group of healthy persons (20 cases), in the group of polycystic renal disease and hepatic cystic disease (18 patients), and in the group of polycystic renal disease (in 32 patients in the serum, and in 28 patients in the urine). No significant differences were found in the values of the enzyme activity in the studied patients in relation to the control group.

Disturbances of platelet function in patients with multiple myeloma.

Coagulation disturbances in patients with multiple myeloma are presented. Platelet disfunction was especially observed, but only in patients with marked hyperproteinemia and a high level of immunoglobulins in plasma, whereas normal adhesion and aggregation were noticed in 3 out of 17 patients without protein disturbances. Chemotherapy as well as plasma exchange caused not only a decrease of the paraprotein level in plasma, but also a normalization of the failure previously observed in platelet function.