Publications by authors named "J Uemasu"
In this study we investigated the effects of N-hexacosanol on streptozotocin-induced rat diabetic nephropathy. Diabetes was induced in 8-week-old male Sprague-Dawley rats by administering an intraperitoneal injection of streptozotocin (50 mg/kg). The rats were divided into four groups and maintained for 8 weeks: control rats, diabetic rats without treatment with N-hexacosanol, and diabetic rats treated with N-hexacosanol (2 mg/kg and 8 mg/kg i.
View Article and Find Full Text PDFWe report a 71-year-old woman with autosomal dominant polycystic kidney disease (ADPKD), who presented with hepatic encephalopathy. She was diagnosed as having ADPKD at 61 years of age. Thereafter, her renal function gradually worsened and she was admitted to our hospital because of encephalopathy and end-stage renal failure.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated the coagulation and fibrinolytic systems in 33 predialysis patients with chronic renal failure, focusing on two groups: 24 with chronic glomerulonephritis (CGN) and 9 with diabetes mellitus (DM).
- Measurements included various complex proteins related to blood clotting and breakdown, revealing that DM patients had higher levels of certain markers compared to those with CGN.
- After 6 months, the study found worsening abnormalities in these coagulation systems for both groups, especially notable in the diabetic patients, indicating a more severe condition.
We investigated the association between angiotensin converting enzyme (ACE) gene polymorphism and clinical manifestations in 47 patients with autosomal dominant polycystic kidney disease (ADPKD). One-hundred, age- and sex-matched subjects with non-ADPKD served as the controls. ACE gene polymorphism was analysed using a GeneAnp kit.
View Article and Find Full Text PDFTo elucidate the possible physiological interaction between growth hormone (GH) and insulin-like growth factor-I (IGF-I) system in human kidney, recombinant human GH (rhGH), which reached a supranormal level of serum GH, was administered, and serum and urinary IGF-I levels were determined in 6 normal men. The first two days served as a pre-control period (preTx). At days 3 and 4 (Tx), 2 U of rhGH was subcutaneously injected twice at 8:00 AM and 8:00 PM.
View Article and Find Full Text PDF