Publications by authors named "J Ueda"
Background: With the advent of effective chemotherapy, conversion surgery (CS) has been performed in patients who have responded to pretreatment, even for pancreatic cancer diagnosed as unresectable (UR) at the time of initial diagnosis. In CS, major arterial resection and reconstruction are necessary for complete radical resection.
Methods: We discuss the key points for safely performing pancreatectomy with celiac axis (CA) resection combined with reconstruction, divided into resection and arterial reconstruction.
Unlabelled: Inherited antithrombin deficiency is an autosomal dominant thrombophilia, resulting from genetic variations in the serpin family C member 1 (SERPINC1) gene. Antithrombin deficiency increases the risk of venous thromboembolism (VTE) compared to the general population. In this report, a novel missense variant of , c.
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- - Takayasu arteritis (TAK) is a serious condition that affects large blood vessels, leading to issues like blockages and aneurysms; it's primarily treated with glucocorticoids, but new biological drugs like tocilizumab are proving effective.
- - Patients on tocilizumab may face higher surgical complications, such as infection or delayed healing, and typically do not show increased inflammatory markers during infections, making management challenging.
- - There is a lack of guidelines for the best perioperative care for TAK patients needing cardiovascular surgery, but this article proposes a protocol based on recent evidence to help reduce complications in these patients.
Article Synopsis
- Recent advancements in drug delivery systems aim to improve brain tumor treatment by bypassing the blood-brain barrier, particularly using cerebrospinal fluid (CSF) for boron neutron capture therapy (BNCT).
- A study conducted at Kyoto University evaluated the effectiveness of BPA delivery via CSF in glioma model rats, comparing it to traditional intravenous (IV) administration.
- Results showed that CSF administration led to comparable tumor treatment efficacy while reducing BPA accumulation in normal tissues and maintaining better overall health in the treated rats.
Article Synopsis
- The study investigates how pathological aggregation of α-synuclein (aSYN) contributes to neuron dysfunction in Parkinson's disease, focusing on mitochondrial impact.
- Researchers injected pre-formed aSYN fibrils into specific mouse brain regions and employed various techniques to analyze the effects 12 weeks later.
- Results showed that aSYN accumulation led to neuronal loss, reduced mitochondrial function, increased oxidative stress, and compromised energy production in dopaminergic neurons, suggesting mitochondrial disruption as an early event in the disease process.