The Intersection of Rurality With Female Sex and Gender in Heart Failure: A Scoping Review Using the Social-Ecological Model.

Background: Despite the increasing recognition of heart failure (HF) as a critical public health issue for both rural populations and women, the intersection of rurality and female sex in HF remains underexplored.

Objective: The objective of this scoping review was to synthesize the evidence on the intersection of rurality with female sex and gender in HF, examining how individual, interpersonal, organizational, or community factors influence the experience, management, and outcomes of HF in women.

Methods: Using the PubMed, Embase, and Cumulative Index to Nursing and Allied Health Literature databases, a literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews.

Cross-species imputation and comparison of single-cell transcriptomic profiles.

Cross-species comparison and prediction of gene expression profiles are important to understand regulatory changes during evolution and to transfer knowledge learned from model organisms to humans. Single-cell RNA-seq (scRNA-seq) profiles enable us to capture gene expression profiles with respect to variations among individual cells; however, cross-species comparison of scRNA-seq profiles is challenging because of data sparsity, batch effects, and the lack of one-to-one cell matching across species. Moreover, single-cell profiles are challenging to obtain in certain biological contexts, limiting the scope of hypothesis generation.

Navigating the Rollercoaster Ride of Adolescence.

Adolescence is often likened to a rollercoaster-a thrilling ride filled with unpredictable highs, sudden drops, and daring twists and turns. For some teenagers, this metaphor becomes even more poignant as they navigate the challenges of burgeoning mood disorders and substance use disorders. These struggles can amplify the turbulence of adolescence, making the ride feel overwhelming not just for the teens experiencing it, but also for the families and caregivers supporting them.

[Lung involvement in connective tissue diseases].

Connective tissue diseases as systemic autoimmune diseases are frequently associated with lung involvement. The diagnostics are often delayed by initially mild and unspecific symptoms. As lung involvement in these diseases can be chronically progressive and sometimes rapidly progressive, early and regular screening and monitoring are essential.