Publications by authors named "J U Rijlaarsdam"
The general psychopathology factor (GPF) has been proposed as a way to capture variance shared between psychiatric symptoms. Despite a growing body of evidence showing both genetic and environmental influences on GPF, the biological mechanisms underlying these influences remain unclear. In the current study, we conducted epigenome-wide meta-analyses to identify both probe- and region-level associations of DNA methylation (DNAm) with school-age general psychopathology in six cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium.
View Article and Find Full Text PDFSleep and mental health in childhood: a multi-method study in the general pediatric population.
Child Adolesc Psychiatry Ment Health
February 2022
Article Synopsis
- - This study examines the relationship between sleep problems and mental health issues in children aged 10-14, noting that sleep problems are common in this demographic and often relate to mental health difficulties.
- - The researchers included 788 children aged 10-11 and 344 aged 13-14, using both mother-reported data and wrist actigraphy to assess sleep patterns and mental health symptoms.
- - Findings indicate that higher reported sleep issues correlate with increased mental health problems, particularly in younger children, although actigraphy data showed limited associations, suggesting a gap between subjective sleep reports and objective sleep measures.
Genetic variants that regulate hypothalamic-pituitary-adrenal (HPA) axis function have been demonstrated to moderate the association between parenting and mental health. However, extant research has focused primarily on (i) effects of individual genes or (ii) maternal as opposed to paternal parenting. Using a multilocus genetic profile score (MGPS) approach, the current study is the first to examine the moderation effect of multilocus HPA-axis related genetic variants on the association of both maternal and paternal parenting with adolescent internalizing and externalizing symptoms.
View Article and Find Full Text PDFBackground: Early difficult temperament and child mental health problems are consistently associated with impaired functioning in adulthood. We examined three potential pathways between difficult temperament in toddlerhood (age 2) and depressive symptoms (ages 21-23) and well-being (age 23): i) direct - early difficult temperament directly associates with these outcomes, ii) mediated - these direct effects are also mediated by a general psychopathology factor in late childhood/early adolescence (GPF; ages 7, 10,and 13), and iii) moderated-mediated - these mediated effects are also moderated by negative (age 42 months) and positive (age 33 months) parenting behaviors.
Methods: The analytic sample included 1892 mother-child dyads (33.
Article Synopsis
- - The study examines how DNA methylation (DNAm) relates to general psychopathology factors (GPF) in children, revealing a connection between specific DNA markers and complex psychiatric symptoms.
- - Researchers analyzed data from 440 10-year-olds, identifying a significant co-methylated module of 218 CpG probes associated with GPF, particularly influenced by the FZD1 gene linked to schizophrenia.
- - The findings were supported by similar results from an independent sample, suggesting that understanding the molecular connections of DNAm could enhance insights into psychiatric disorders.