[Therapeutic plasma exchanges with cyclophosphamide in the treatment of rapidly progressing glomerulonephritis].

On the basis of two cases of rapidly progressive glomerulonephritis with over 50% crescents in percutaneous renal biopsy, anti-GBM antibodies in one case and progressive renal failure in both cases, successful treatment with plasma exchanges and aggressive immunosuppression according to our own protocol is presented and discussed with literature.

[Acute intermittent porphyria: actual problems of clinical and laboratory diagnosis].

On the case of 27 old woman with clinical symptoms of acute abdomen, severe electrolyte disturbances and attacks of grand mal seizures, different clinical masks and actual treatment guidelines of acute intermittent porphyria are presented. Among laboratory methods detecting precursors of hem in the urine, high-performance liquid chromatography (HPLC) as the most sensitive and specific method is recommended. Proper prophylaxis against new episodes of acute intermittent porphyria as well as long lasting ambulatory care of the patient are emphasized.