Publications by authors named "J Turgeon"
Introduction: Animal models suggest a protective role of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin-II receptor blockers (ARBs) in reducing renal and cardiac ischemia-reperfusion injury. Our aim was to determine the association between pre-transplant ACEi/ARBs use and the occurrence of delayed graft function (DGF) in patients who received a kidney transplantation from a deceased donor.
Methods: Consecutive recipients between 2008 and 2021 in 2 Canadian university-affiliated centers were included in this retrospective cohort study.
Glucokinase (GK) catalyses the key regulatory step in glucose-stimulated insulin secretion. Correspondingly, hetero- and homozygous mutations in human cause maturity-onset diabetes of the young (GCK-MODY) and permanent neonatal diabetes (PNDM), respectively. To explore the possible utility of glucokinase activators (GKA) and of glucagon-like receptor-1 (GLP-1) agonists in these diseases, we have developed a novel hypomorphic allele in mice encoding an aberrantly spliced mRNA deleted for exons 2 and 3.
View Article and Find Full Text PDFBiological invasions pose significant threats to ecological and economic stability, with invasive pests like the Asian longhorned beetle ( Motschulsky, ALB) causing substantial damage to forest ecosystems. Effective pest management relies on comprehensive knowledge of the insect's biology and invasion history. This study uses genomics to address these knowledge gaps and inform existing biosurveillance frameworks.
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- - This study investigates how the medications propofol and fentanyl behave in the body (PK/PD) in patients using veno-venous extracorporeal membrane oxygenation (V-V ECMO) due to a lack of existing data in this area.
- - Conducted at Toronto General Hospital ICU, the research involved 11 patients monitored over a median of 146 hours, revealing that both medications follow a two-compartment model for clearance and that over-sedation was common despite increased clearance rates shortly after ECMO began.
- - Results show that while clearance of sedatives increased temporarily after ECMO initiation and differences were noted based on sex, sedation effectiveness varied and respiratory effort was inconsistent regardless of medication levels.
According to a central tenet of classical immune theory, a healthy immune system must avoid self-reactive lymphocyte clones but we now know that B cells repertoire exhibit some level of autoreactivity. These autoreactive B cells are thought to rely on self-ligands for their clonal selection and survival. Here, we confirm that healthy mice exhibit self-reactive B cell clones that can be stimulated by agonists of toll-like receptor (TLR) 1/2, TLR4, TLR7 and TLR9 to secrete anti-LG3/perlecan.
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