Publications by authors named "J Tudela"
Article Synopsis
- The study investigates how specific immune cell types in blood samples from patients with metastatic castration-resistant prostate cancer (mCRPC) can affect survival rates.
- Researchers analyzed pre-treatment blood samples from 152 patients and found that lower CD8 T-cell counts and higher monocyte levels were linked to shorter survival.
- Their results suggest that these immune cell types could act as important biomarkers for mCRPC management, supporting the need for further research in clinical trials.
Phenolic compounds with a position ortho to the free phenolic hydroxyl group occupied can be tyrosinase substrates. However, ortho-substituted compounds are usually described as inhibitors. The mechanism of action of tyrosinase on monophenols is complex, and if they are ortho-substituted, it is more complicated.
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- This study investigates the effectiveness of different disinfectants, including free chlorine, chlorine dioxide, and peracetic acid, in reducing viruses in produce wash water to enhance food safety against human norovirus outbreaks.
- Results revealed that free chlorine was highly effective, inactivating over 8 logs of human norovirus in just 1 minute, while chlorine dioxide and peracetic acid had variable success.
- The research also introduces a predictive model for virus inactivation that can help optimize post-harvest safety protocols in the fresh produce industry.
Article Synopsis
- - Functional T regulatory cells (Tregs) hinder anticancer immunity and play a significant role in tumor growth by developing in response to the tumor's environment.
- - Researchers identified a tumor-derived carbohydrate called A10 (Ca10), which enhances glycolysis and promotes Treg development through various mechanisms involving metabolic changes and inflammatory signals.
- - The study shows that higher levels of Ca10 in the serum correlate with tumor size and Treg counts in mice, and similar elevated levels of a human counterpart (Ca10H) are found in cancer patients, especially those with metastatic disease, suggesting new avenues for cancer therapies.