Publications by authors named "J Tsay"
Background: While it is evident that stroke impairs motor control, it remains unclear whether stroke impacts motor adaptation-the ability to flexibly modify movements in response to changes in the body and the environment. The mixed results in the literature may be due to differences in participants' brain lesions, sensorimotor tasks, or a combination of both.
Objective: We first sought to better understand the overall impact of stroke on motor adaptation and then to delineate the impact of lesion hemisphere and sensorimotor task on adaptation poststroke.
Article Synopsis
- * The research involved 1,605 adolescents from a drug prevention program in Taiwan and examined data on intervention services, alongside comparisons to a larger general population cohort, using police records to confirm drug use.
- * Key findings showed that while many users were primarily involved with ketamine, early school dropout increased the risk of reinitiated drug use, whereas support services for at-risk families significantly reduced this risk, emphasizing the need for effective school-based intervention strategies.
Lung allograft dysbiosis associates with immune response and primary graft dysfunction.
J Heart Lung Transplant
November 2024
Article Synopsis
- Lower airway dysbiosis, characterized by an increase in specific bacteria, is linked to various severity grades of primary graft dysfunction (PGD) after lung transplantation, particularly in moderate and severe cases.
- A study involving lower airway samples from 96 lung transplant recipients showed correlations between PGD severity and elevated levels of inflammatory markers, particularly neutrophils and specific cytokines, indicating a distinct inflammatory response.
- Results suggest that microbial differences may influence host immune signaling, potentially exacerbating inflammation and contributing to PGD pathogenesis, highlighting the importance of microbial balance in lung health post-transplant.
Lung Microbial and Host Genomic Signatures as Predictors of Prognosis in Early-Stage Adenocarcinoma.
Cancer Epidemiol Biomarkers Prev
November 2024
Article Synopsis
- This study explores the significant risk of recurrence in early-stage lung adenocarcinoma after surgical removal, noting that current methods lack biomarkers for prediction.
- Researchers analyzed 91 patients' tumor and nearby unaffected lung tissue using specialized gene sequencing techniques to identify potential microbial and host genomic factors associated with recurrence.
- Results revealed specific bacterial enrichments linked to recurrence in both tumor (e.g., Dialister) and unaffected lung samples (e.g., Sphingomonas), with a combined model showing strong predictive performance for recurrence using unaffected lung samples (AUC = 0.83).
Motor learning is often viewed as a unitary process that operates outside of conscious awareness. This perspective has led to the development of sophisticated models designed to elucidate the mechanisms of implicit sensorimotor learning. In this review, we argue for a broader perspective, emphasizing the contribution of explicit strategies to sensorimotor learning tasks.
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