Guidance to inform research recruitment processes for studies involving critically ill patients.

Clinical research in intensive care units (ICUs) is essential for improving treatments for critically ill patients. However, invitations to participate in clinical research in this situation pose numerous challenges. Studies are frequently initiated within a narrow time window when patients are often unconscious and unable to consent.

Motor control of the palatoglossus and genioglossus during changes in breathing route.

High activity of upper airway dilator muscles is thought to be critical in preventing sleep-related upper airway collapse. To date, most of the research regarding upper airway dilator muscles has focused on the genioglossus muscle, which protrudes the tongue and opens the retroglossal airway. However, collapse commonly occurs in the retropalatal region.

An Informatics Platform for the Management of Data for Australian Dementia Network (ADNeT) Initiative.

Alzheimer's disease and other dementias are becoming more prevalent and placing increasing burdens on the community. The ADNeT Screening and Trials initiative aims to improve research outcomes by identifying people with an increased risk of developing these diseases and directing them to suitable clinical trials. To support the initiative, we have developed a modular informatics platform utilizing private cloud deployment to securely manage operational and research data across six clinical sites.

Best practice recommendations for medically assisted reproduction in patients with known cardiovascular disease or at high risk of cardiovascular disease.

Increasing numbers of people are seeking assisted conception. In people with known cardiac disease or risk factors for cardiac disease, assisted conception may carry increased risks during treatment and any subsequent pregnancy. These risks should be assessed, considered and minimized prior to treatment.