Publications by authors named "J Trejo"
Signaling by G protein-coupled receptors (GPCRs) is regulated by temporally distinct processes including receptor desensitization, internalization, and lysosomal sorting, and are tightly controlled by post-translational modifications. While the role of phosphorylation in regulating GPCR signaling is well studied and established, the mechanisms by which other post-translational modifications, such as ubiquitination, regulate GPCR signaling are not clearly defined. We hypothesize that GPCR ubiquitination and deubiquitination is critical for proper signaling and cellular responses.
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- The study investigates the effects of ABO compatibility on platelet transfusion outcomes in patients with spontaneous and traumatic intracranial hemorrhage (ICH).
- It hypothesizes that ABO-identical transfusions would result in better post-transfusion platelet increments and improved neurologic outcomes compared to incompatible transfusions.
- Results show no significant differences in platelet increments or clinical outcomes among patients receiving ABO-identical, major incompatible, or minor incompatible transfusions, suggesting ABO compatibility may not be as crucial as previously thought.
Introduction: Human metabolomics has made significant strides in understanding metabolic changes and their implications for human health, with promising applications in diagnostics and treatment, particularly regarding the gut microbiome. However, progress is hampered by issues with data comparability and reproducibility across studies, limiting the translation of these discoveries into practical applications.
Objectives: This study aims to evaluate the fit-for-purpose of a suite of human stool samples as potential candidate reference materials (RMs) and assess the state of the field regarding harmonizing gut metabolomics measurements.
Article Synopsis
- * In addition to its effects on glucose metabolism, insulin affects reproductive health by suppressing the secretion of gonadotropins from the pituitary gland, particularly in states of high insulin levels (hyperinsulinemia).
- * Research using LβT2 gonadotropic cells reveals that insulin stimulation leads to the unexpected movement of GLUT1 transporters to the cell membrane, occurring independently of the typical Akt signaling pathway, suggesting a complex role for insulin in these cells.
Direct evidence for ultrastructures of the α-synuclein-associated synaptic vesicle pool in presynaptic terminals.
Biochim Biophys Acta Mol Basis Dis
December 2024
SNCA/PARK1 encodes α-synuclein, which is associated with familial Parkinson's disease. Despite its abundance in presynaptic terminals, the aggregation mechanism of α-synuclein and its relationship with Parkinson's disease have not yet been elucidated. Moreover, the ultrastructures of α-synuclein localization sites in neuronal presynaptic terminals remain unclear.
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