Publications by authors named "J Travis Hinson"
Objectives: Exploiting the complete blood count (CBC) with differential (CBC-diff) for early sepsis detection has practical value for emergency department (ED) care, especially for those without obvious presentations. The objective of this study was to develop the CBC Sepsis Index (CBC-SI) that incorporates monocyte distribution width (MDW) to enhance rapid sepsis screening.
Design: A retrospective observational study.
Sepsis and septic shock are global healthcare problems associated with high mortality rates. Activation of the renin-angiotensin-aldosterone system (RAAS) is an early event in sepsis and elevated renin may be predictive of worse outcomes. In a subset of sepsis patients enrolled in the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) trial, active renin (median value > 189 pg/mL or 5.
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- * This study highlights that serum Angiotensinogen levels are better indicators of 30-day mortality in sepsis patients than lactate or renin levels, suggesting a dysfunctional renin-angiotensin system in these cases.
- * Evaluating Angiotensinogen could improve treatment strategies for sepsis, potentially leading to better patient outcomes, but further studies are needed to validate its effectiveness as a biomarker.