Publications by authors named "J Trauet"
Techniques currently used for the study of antigen-specific T-cell responses are either poorly informative or require a heavy workload. Consequently, many perspectives associated with the broader study of such approaches remain mostly unexplored in translational research. However, these could benefit many fields including but not limited to infectious diseases, oncology, and vaccination.
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- This study explored the effectiveness of the BNT162b2 booster vaccine on neutralizing antibodies and T cell responses in healthcare workers against the Omicron sublineages BA.1 and BA.2, before and three months after vaccination.
- Results showed that before the booster, a small percentage of participants had measurable neutralizing activity, but by three months post-booster, nearly all had developed strong antibody responses against Delta and Omicron variants, although the levels were lower for BA.1 and BA.2 than for Delta.
- Participants with recent SARS-CoV-2 infections maintained stable antibody levels, while those without infections experienced a decrease in neutralizing antibody titres over the three-month period.
Immunogenicity of BNT162b2 vaccine booster against SARS-CoV-2 Delta and Omicron variants in nursing home residents: A prospective observational study in older adults aged from 68 to 98 years.
Lancet Reg Health Eur
June 2022
Background: The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents.
Methods: In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts, serum neutralizing antibody titers against Delta and Omicron variants were compared before and up to three months after the BNT162b2 booster dose, in NH residents without COVID-19 (COVID-19 naive) or with COVID-19 prior to initial vaccination (COVID-19 recovered).
Findings: 106 NH residents (median [interquartile range] age: 86·5 [81;91] years) were included.
Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to focus on the specific T-cell response.
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