Publications by authors named "J Tramper"
Article Synopsis
- Pathogenic variants in a specific gene significantly increase the risk of developing heritable pulmonary arterial hypertension, and examining unaffected carriers through advanced screening methods can help in early diagnosis and understanding of the condition.
- A study compared 28 unaffected carriers to 21 healthy controls using various cardiac imaging and exercise tests; findings revealed carriers had smaller heart volumes but higher afterload, indicating potential early signs of the disease.
- Over a 4-year follow-up, two unaffected carriers went on to develop pulmonary arterial hypertension, despite showing normal cardiac indices at the time of diagnosis, highlighting the importance of monitoring these individuals for early intervention.
Article Synopsis
- The study examines how pulmonary endarterectomy (PEA) affects hemodynamics and exercise capacity in patients with chronic thromboembolic pulmonary hypertension (CTEPH) classified as mild or severe based on their mean pulmonary arterial pressure (mPAP).
- 18 CTEPH patients were evaluated before and 18 months after PEA, revealing that those with mild CTEPH had less impairment in exercise capacity at baseline compared to the severe group.
- Post-surgery, both groups showed improvements in hemodynamics, but only the severe group experienced a significant increase in exercise capacity, suggesting postoperative outcomes were similar despite initial differences in severity.
Chronic thromboembolic pulmonary hypertension (CTEPH) has a poor prognosis if left untreated but can be cured by pulmonary endarterectomy (PEA). Massive endobronchial pulmonary hemorrhage is a potentially fatal complication of PEA, occurring in 0.5%of patients.
View Article and Find Full Text PDFPulmonary arterial hypertension is a heterogeneous group of diseases characterized by vascular cell proliferation leading to pulmonary vascular remodelling and ultimately right heart failure. Previous data indicated that 3'-deoxy-3'-[18F]-fluorothymidine (FLT) positron emission tomography (PET) scanning was increased in pulmonary arterial hypertension patients, hence providing a possible biomarker for pulmonary arterial hypertension as it reflects vascular cell hyperproliferation in the lung. This study sought to validate FLT-PET in an expanded cohort of pulmonary arterial hypertension patients in comparison to matched healthy controls and unaffected bone morphogenetic protein receptor type 2 mutation carriers.
View Article and Find Full Text PDFThis article describes a systematic approach to analysing patients with hypoxaemia. The article is intended for anyone dealing with patients with reduced oxygen saturation during rest or exercise. Hypoxaemia has various causes.
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