Publications by authors named "J Tordjman"
Background: Over-expression of cyclooxygenase (COX)-2 promotes breast cancer progression by multiple mechanisms, including induction of stem-like cells (SLC). Combined gene expression and microRNA microarray analyses of empty vector vs COX-2- transfected COX-2 low MCF7 breast cancer cell line identified two COX-2-upregulated microRNAs, miR-526b and miR-655, both found to be oncogenic and SLC-promoting. Cytoplasmic Polyadenylation Element-Binding Protein 2 (CPEB2) was the single common target of both microRNAs, the functions of which remain controversial.
View Article and Find Full Text PDFContext: Bariatric surgery (BS) induces major and sustainable weight loss in many patients. Factors predicting poor weight-loss response (PR) need to be identified to improve patient care. Quantification of subcutaneous adipose tissue (scAT) fibrosis is negatively associated with post-BS weight loss, but whether it could constitute a predictor applicable in clinical routine remains to be demonstrated.
View Article and Find Full Text PDFObjectives: The complexity of partial nephrectomy (PN) is partly anticipated by morphometric tumor-based scores that do not consider patient-related issues such as adherent perinephric fat (APF). Also, the objective is to prospectively assess the predictive factors of APF during PN, its effect on complications, and to correlate it to the histological reality.
Methods: A total of 125 consecutive patients undergoing robotic or open PN were prospectively included.
Objectives: Compared with subcutaneous adipose tissue (SCAT), infrapatellar fat pad (IFP), the main knee intra-articular adipose tissue (IAAT), has an inflammatory phenotype in patients with osteoarthritis (OA). We phenotyped suprapatellar fat pad (SPFP) and hip acetabular fat pad (AFP), two other IAATs, to determinate the unique signature of IAATs compared with SCAT.
Methods: IFP, SPFP, AFP and autologous SCAT were obtained from patients with OA during total knee (n=38) or hip replacement (n=5).
Article Synopsis
- Non-alcoholic fatty liver disease (NAFLD) is a common issue in severely obese patients, but its severity can vary greatly, highlighting the need for more research into its progression.
- A study examined liver biopsies from 798 obese patients undergoing bariatric surgery, comparing their liver health with factors like age, obesity duration, and body fat distribution.
- Results showed younger individuals (age 37) typically had normal liver conditions while older patients (age 44) had NAFLD, and an increase in trunk to limb fat ratio correlated with more severe liver disease, especially in women.