Publications by authors named "J Topinka"
Exposure of cell cultures at air-liquid interface (ALI), mimicking i.e. human lung surface, is believed to be one of the most realistic means to model toxicity of complex mixtures of pollutants on human health.
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- Polycyclic aromatic hydrocarbons (PAHs), like benzo[a]pyrene (BaP), arise from incomplete combustion and are found in sources like tobacco smoke and charbroiled food, posing cancer risks.
- Researchers genetically modified the nematode Caenorhabditis elegans to include human CYP1A1, CYP1A2, and epoxide hydrolase to study the effects of BaP exposure, observing changes in behavior and reproductive performance, such as increased pharyngeal pumping and decreased brood size.
- The findings revealed that the humanized worms experienced more severe reproductive toxicity and genetic mutations when exposed to BaP, highlighting the potential of these modified organisms for improving research practices while working towards the
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- Studies link living near major roads to a higher risk of Alzheimer's disease (AD), but the exact mechanisms are unclear.
- Exposure to diesel emissions (DE) was analyzed in olfactory mucosa cells from both healthy individuals and AD patients, revealing that AD cells showed nearly four times greater sensitivity to DE.
- DNA methylation patterns changed in response to DE exposure, identifying potential biomarkers and pathways involved, particularly highlighting the role of NRF2 signaling in cellular responses to air pollution.
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- * UFP samples were taken from exhausts of different diesel engines, and researchers exposed OM cells from both cognitively healthy individuals and those with AD to these particles for varying durations.
- * Findings indicate that UFPs impair important cellular functions such as oxidative phosphorylation and redox balance, with unique responses observed in AD cells compared to healthy controls, suggesting a potential link between air pollution and neurodegenerative diseases.
The aim of this study was to investigate the relationship between source-specific ambient particulate air pollution concentrations and the incidence of dementia. The study encompassed 70,057 participants from the Västerbotten intervention program cohort in Northern Sweden with a median age of 40 years at baseline. High-resolution dispersion models were employed to estimate source-specific particulate matter (PM) concentrations, such as PM and PM from traffic, exhaust, and biomass (mainly wood) burning, at the residential addresses of each participant.
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