Publications by authors named "J Toke"
Objective: The mainstay therapy of hypothyroidism is levothyroxine (LT4). In most cases lifelong treatment is warranted, therefore, choosing adequate doses are of paramount significance. The purpose of this study was to assess several factors that have been proposed to influence LT4 therapy including etiology of hypothyroidism, gender, age, bodyweight, BMI, concomitant drug use, disease severity and time since diagnosis in patients with stable, adequately controlled hypothyroidism.
View Article and Find Full Text PDFPurpose: Medullary thyroid carcinoma (MTC) in MEN2B syndrome is associated with germline mutation. Patients harboring de novo mutations are usually diagnosed at more advanced disease stages. We present a young woman with Met918Th mutation diagnosed with stage IV MTC at age 10 years.
View Article and Find Full Text PDFArticle Synopsis
- Cowden syndrome (CS) is a rare genetic disorder linked to mutations in the PTEN tumor suppressor gene, increasing the risk of various tumors, including thyroid and breast cancers.
- A case study highlights a 46-year-old man with a history of testicular seminoma and thyroid cancer who was diagnosed with CS through genetic testing that confirmed a PTEN mutation.
- This patient also exhibited multiple pulmonary carcinoid tumors, marking him as the first reported case of CS linked to these specific tumors, suggesting CS may predispose individuals to multifocal pulmonary lesions.